Science Pulse

Dr. Givens's picture
March 03, 2014

A common problem for many of our IVF patients is diminished ovarian reserve (DOR). This happens naturally as we get older but unfortunately, can also occur at earlier ages in some women. When a patient has DOR, she will typically have a higher Follicle Stimulating Hormone (FSH) level, a low Anti-Mullerian Hormone (AMH) level or low numbers of antral (small) ovarian follicles. She may have just one or two of these findings, or all of them. Not untypically, women with this problem will require large doses of injectable ovarian stimulating fertility medications to achieve a reasonable response to do IVF (e.g. four or more mature follicles).

Dr. Givens's picture
March 25, 2013

If you have been following Fertility Flash newsletters, you may have noticed several recent articles about Comprehensive Chromosomal Screening (CCS). CCS is the process of analyzing blastocyst-stage embryos for chromosomal make-up. This process helps to ensure that embryos transferred to a patient have the proper number of chromosomes (i.e. 46XX or 46XY) and do not have abnormalities that could result in failed implantation, miscarriage or an abnormal fetus at the time of amniocentesis or birth. We at Pacific Fertility Center have taken the lead in developing and promoting CCS for many of our patients. 2012 was a banner year for the emergence and application of this technology for patients undergoing in vitro fertilization.

Dr. Chenette's picture
January 29, 2013

Embryo selection is no small matter in an embryology lab. Choosing high-quality embryos is critical to improving implantation rates, reducing multiple pregnancies, and improving pregnancy outcomes while reducing risk.

Continuing its development of new technology to assess embryo quality, Pacific Fertility Center (PFC) was the first embryology lab in the nation to install the Early Embryo Viability Assessment (Eeva) System from Auxogyn, Inc. Eeva is a time-lapse imaging technique that helps select the best quality embryos for transfer.

Dr. Ryan's picture
January 28, 2013

No longer experimental. That was the much-anticipated statement about egg (oocyte) freezing coming from the American Society of Reproductive Medicine (ASRM) on October 19, 2012. The statement came after much work and deliberation by ASRM experts, who reviewed the world literature on the effectiveness and safety of egg freezing and, most importantly, on the desired outcome: healthy babies.

Safe and effective
The European Society of Human Reproduction and Embryology (ESHRE) had endorsed oocyte freezing as a standard and safe procedure in March of 2012. So many of us were waiting with bated breath for ASRM to also endorse egg freezing as an appropriate and safe procedure for our patients in the United States. 

Dr. Li's picture
By Dr. Li
January 21, 2013

Genetic Screening: Updates from ASRM

The American Society for Reproductive Medicine (ASRM) is a multidisciplinary professional organization devoted to the advancement of science and clinical practice of reproductive medicine, patient and provider education, and advocacy. Each year, ASRM members gather for a scientific meeting where researchers in the field present new findings. As members of ASRM, many of PFC’s staff have consistently attended and participated in the Annual Meeting, often making presentations and moderating sessions.

This year, a hot topic at the ASRM Annual Meeting in San Diego was comprehensive chromosome screening (CCS), a technique that allows screening of embryos for genetic problems prior to implantation previously known as preimplantation genetic screening (PGS). There were 27 presentations on CCS.