PGS - Preimplantation Genetic Screening

PFC Team's picture
November 15, 2016

Preimplantation genetic screening (PGS) has improved pregnancy and birth outcomes for women undergoing in vitro fertilization (IVF), especially in women at risk for an abnormal number of chromosomes (aneuploidy). Advances in PGS have even made it possible to spot a condition called mosaicism. Varying in severity, mosaicism is an early error in cell division that results in two or more cell lines with different genetic makeup.

The sophisticated knowledge gleaned through advanced methods of PGS, however, poses a challenge to reproductive endocrinologists: Should they transfer embryos with low-level mosaicism—embryos that may still result in healthy live births?

Parsing mosaicism. An observational study examined the rate of low-level mosaicism in blastocysts with a normal complement of chromosomes (euploid) to blastocysts where no mosaicism was detected.1

PFC Team's picture
September 08, 2016

Last May in Bologna, Italy, Pacific Fertility Center staff attended the 15th International Conference on Preimplantation Genetic Diagnosis—a gathering that brings together experts in the field of genetics and reproductive endocrinology. This year’s conference covered wide-ranging topics such as innovations in embryo biopsy, mitochondrial DNA, and Next Generation Sequencing (NGS), the newest platform for genetic testing and a subject of hearty debate.

PFC Team's picture
March 11, 2016

San Francisco, CA – March 11, 2016 – Today at 6:00 pm at the 2016 Annual Meeting of the Pacific Coast Reproductive Society (PCRS) in Rancho Mirage, CA, Pacific Fertility Center (PFC) staff will present their research findings on pregnancy from embryos that have been cultured to Day 7 (D7).

One of the first to focus on the number of chromosome sets (ploidy) and implantation rate of D7 embryos, the study provides the largest data set available on pregnancy outcomes after transfer of D7 blastocysts (embryos at an early stage of development). This is PFC’s second paper on D7 embryos—and one of only a few in the literature, said senior author, Philip Chenette, MD.

Reviewing embryology records from March 2014 to July 2015, PFC researchers looked only at blastocysts on Day 5, 6, or 7.  Of the 5,103 embryos frozen at the blastocyst stage, 816 (16 percent of the total) were frozen on D7 and 53 of these were later transferred to attempt pregnancy.

Dr. Li's picture
By Dr. Li
December 20, 2011

ASRM 2011 Updates In addition to the magical wonders of Disney, Orlando welcomed reproductive endocrinologists from around the world this October to attend the annual meeting of The American Society for Reproductive Medicine (ASRM).  Several members of Pacific Fertility Center were among the participants. 

PFC Team's picture
July 12, 2011

PCRS Meeting Review

Pacific Fertility Center’s team directed the Pacific Coast Reproductive Society’s annual meeting in April this year.  Dr. Carolyn Givens was President of the Society and Dr. Joe Conaghan was Program Co-Chair at the meeting this year.  And what a meeting it was!

Optimizing success rates for patients was the focus, with presentations on “Improving Live Birth Rates”, videos on the importance of early embryo development, optimizing treatment protocols, and early embryo testing.  There were sessions on stress reduction, discussions on single embryo transfer, healthy debates between experts, and conversations about new advances that will improve patient care.

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