IVF - In Vitro Fertilization

PFC Team's picture
December 06, 2017

Which type of transfer—fresh or freeze-only—leads to higher implantation and ongoing pregnancy rates (OPR)? A recent study was the largest to make this comparison, finding that freeze-only transfers are often the clear winners.1 Why is this so? It may have something to do with the delicate “dance” between the embryo and the lining of the uterus (endometrium).

Reproductive synchrony. For implantation to be successful, this embryo-endometrial dance must be well choreographed. The embryo must bring the right complement of chromosomes to its “dance partner,” and the endometrium must establish an environment that’s welcoming for the embryo. A receptive endometrium depends upon endometrial gene expression as well as responses to hormones throughout different phases of the menstrual cycle.

Dr. Conaghan's picture
May 24, 2017

PFC has been a pioneer in enabling patients to have just a single embryo transferred at a time, through the use of genetic testing and freezing of embryos for later use.  At PFC we elect to transfer one embryo in over 90% of patients and our twin rate is 6%. Nationally, clinics perform elective single embryo transfer in less than 30% of patients.  North America has consistently had the highest multiple pregnancy rates in the world but this is changing and should continue to change with the new guidelines for number of embryos to transfer.

The numbers tell the tale: Transferring a single embryo has become a big success story (but we already knew that—and you probably did too).

Dr. Herbert's picture
March 15, 2017

PFC's Dr. Carl Herbert was interviewed by SELF online magazine in response to a Texas woman's viral Facebook post about her long journey to pregnancy.

“If we don’t get a positive pregnancy [test], we start to wonder what else could be wrong,” said Dr. Herbert.

You can read the full article on SELF magazine online here.

PFC Team's picture
November 17, 2016

After in vitro fertilization (IVF), why do male embryos disproportionately survive the developmental journey to live birth? A retrospective analysis zeroed in on the specific association between blastocyst-stage embryo transfers and a higher proportion of male embryos—examining whether these transfers ultimately result in more male live births.1

The study methods. In the study, 535 patients underwent IVF using their own eggs and intracytoplasmic sperm injection (ICSI), using sperm from males with no severe male factor infertility. Next:

PFC Team's picture
November 16, 2016

Only 1 in 4 infertile couples in the U.S. can afford the fertility care they need to achieve pregnancy. Some even turn to crowdfunding to help close the spending gap.

ASRM efforts. The American Society for Reproductive Medicine (ASRM) has begun to explore strategies for broadening access to care. A year ago, ASRM held a summit meeting in Washington, DC and created a task force to follow through on potential solutions such as the use of private foundations.  It conducted an observational study to explore their feasibility.1

A foundation for success. The researchers worked with the Kevin J. Lederer Life Foundation, which is a collaborative effort among Chicago-area fertility practices to promote health and alleviate the mental and physical challenges of those who are infertile. It does this through financial contributions and educational events on topics such as egg vitrification and male factor infertility.