CCS - Comprehensive Chromosome Screening

PFC Team's picture
November 18, 2016

The United States and Canada have the world’s highest rate of multiple pregnancies following fertility treatments.  This is in part due to lack of regulation, but also results from patients and physicians aggressively transferring multiple embryos at once in the hope of achieving any pregnancy.  The result is that almost half the pregnancies are twins and a significant number of triplet and high-order multiple pregnancies are still occurring1.  These are all high risk pregnancies with likely complications and health problems for mother and babies that are significantly reduced in singleton pregnancies.

PFC Team's picture
November 17, 2016

After in vitro fertilization (IVF), why do male embryos disproportionately survive the developmental journey to live birth? A retrospective analysis zeroed in on the specific association between blastocyst-stage embryo transfers and a higher proportion of male embryos—examining whether these transfers ultimately result in more male live births.1

The study methods. In the study, 535 patients underwent IVF using their own eggs and intracytoplasmic sperm injection (ICSI), using sperm from males with no severe male factor infertility. Next:

PFC Team's picture
November 10, 2016

Fewer multiples after single embryo transfer and Comprehensive Chromosome Screening (CCS) is a clear benefit, but does it make IVF less cost-effective overall?

Researchers from New Jersey recently explored this very question. They compared the overall costs of CCS and chromosomally normal (euploid) single embryo transfers (SETs) with SETs of unscreened embryos.1 Understanding these cost comparisons is important, especially given that the cumulative live birth rate per stimulation cycle is the same for both types of cycles.

The mathematical model. The researchers created a mathematical model to determine the average number of unscreened SET cycles required to produce either a live birth or to exhaust all embryos produced from a single retrieval. Based on actual outcome data, they assumed a baseline fresh embryo transfer rate of 30 percent for unscreened SETs.

Dr. Herbert's picture
October 25, 2016

PFC’s Dr. Carl Herbert was interviewed by SELF Magazine about the benefits of going through fertility treatment before age 40. Dr. Herbert also spoke to the benefits of testing embryos for any genetic abnormalities, which can increase a woman's odds of having a healthy baby to nearly 60%.

You can read the full article on SELF magazine online here.

PFC Team's picture
September 08, 2016

Last May in Bologna, Italy, Pacific Fertility Center staff attended the 15th International Conference on Preimplantation Genetic Diagnosis—a gathering that brings together experts in the field of genetics and reproductive endocrinology. This year’s conference covered wide-ranging topics such as innovations in embryo biopsy, mitochondrial DNA, and Next Generation Sequencing (NGS), the newest platform for genetic testing and a subject of hearty debate.